Antibody basic unit
It consists of two heavy chains (blue, yellow) and two light chains (green, pink). One of the two antigen-binding regions is circled: they are formed by the variable regions at the tip of the antibody. The heavy chains have (starting from the N-terminus at the tip) a variable domain (VH), followed by a constant domain (CH1), a hinge region, and two more constant domain (CH2, CH3). The light chains have a variable domain (VL) and a constant domain (CL).
The CH2 and CH3 regions form the crystallizable fragment (Fc). The variable and CH1, CL regions form a pair of antigen-binding fragments (Fab).
Disulfide bonds between the chains are drawn as S-S. Their exact number and location varies for different isotypes.Mer information om licensen för bilden finns här. Senaste uppdateringen: Thu, 14 Sep 2023 00:15:04 GMT